Frequent Questions

What is meant by the Lower Limit Of Quantitation (LLOQ) for SW-846 test methods?

What is LLOQ?


SW-846 Chapter One defines the Lower Limit Of Quantitation (LLOQ) as: The lowest point of quantitation which, in most cases, is the lowest concentration in the calibration curve.  The LLOQ is initially verified by spiking a clean control material (e.g., reagent water, method blanks, Ottawa sand, diatomaceous earth, etc.) at the LLOQ and processing through all preparation and determinative steps of the method.  Laboratory-specific LLOQ recovery limits should be established when sufficient data points exist.  See Section 9 of Methods 8000D and 6010D/6020B for additional guidance in establishing, implementing and verifying LLOQs for organic and inorganic analytes.  LLOQs should be determined at a frequency established by the method, laboratory’s quality system, or project.

Other category: QA/QC

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